A monoclonal antibody which recognized the functional site of snake neurotoxins and which neutralizes all short-chain variants.
نویسندگان
چکیده
We isolated a neurotoxin-specific monoclonal antibody (Mab) which is capable of recognizing and neutralizing all short-chain toxin variants that have been tested, including those with widely divergent sequences. The epitope incorporates the three invariant residues Lys-27, Trp-29 and Lys-47 which form part of the site by which the toxins bind to the nicotinic acetylcholine receptor. To our knowledge, this is the first Mab which possesses the universal capacity of neutralizing all natural variants of a toxic protein.
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عنوان ژورنال:
- FEBS letters
دوره 208 2 شماره
صفحات -
تاریخ انتشار 1986